What is the normal oxygen demand and supply for the myocardium at rest and during exercise?

At rest, the myocardium's oxygen demand and supply are balanced at 3 oxygen units per second. During exercise, both increase to 9 oxygen units per second due to increased coronary blood flow.

CAD — main cause?

Atherosclerosis (95%)

How does an imbalance between oxygen demand and supply manifest in ischemic heart disease?

When oxygen demand exceeds supply, especially during exertion, it leads to myocardial ischemia, which manifests clinically as angina or other ischemic symptoms.

Stable angina — relief?

Relieved by rest or nitroglycerin

What is myocardial ischemia and how does it relate to imbalance in oxygen supply and demand?

Myocardial ischemia occurs when there is an imbalance between myocardial oxygen demand and supply, typically due to reduced blood flow from coronary artery problems, leading to insufficient oxygen being delivered to the heart muscle during increased demand such as exertion.

ECG signs — ischemia, injury, necrosis?

T wave inversion, ST elevation, Q waves