Flashcards: Fundamentals of Immunology — 18 cartões

Immune system organization — main components?

Innate and adaptive immunity

Cellular actors — key lymphocytes?

B cells, T cells, NK cells

Pathogen recognition — primary molecules?

Antigens and pattern recognition receptors

Innate immunity components?

Physical barriers, phagocytes, complement, PRRs

Adaptive immunity components?

B cells, T cells, antibodies, MHC molecules

Cell signaling — key molecules?

Receptors, cytokines, second messengers

Lymphocyte development — primary organs?

Bone marrow (B cells), thymus (T cells)

Antigen recognition — main process?

Receptors bind specific epitopes on antigens

Historical vaccination — key discovery?

Edward Jenner's smallpox vaccine (1796)

Immunological techniques — common method?

ELISA for detecting antigens or antibodies

Innate immunity — recognition mechanism?

PRRs detect PAMPs and DAMPs

Adaptive immunity — recognition mechanism?

BCRs and TCRs recognize specific epitopes

Pathogen recognition — innate vs adaptive?

Innate: PAMPs; Adaptive: specific epitopes

Lymphocyte maturation site — B cells?

Bone marrow

Lymphocyte maturation site — T cells?

Thymus

Antigen presentation — key molecules?

MHC class I and II

V(D)J recombination — purpose?

Generate receptor diversity

Clonal selection — process?

Proliferation of specific lymphocytes upon antigen recognition