Flashcards: Flavivirus Biology and Disease Mechanisms — 21 cards

Flaviviruses — classification?

Positive-sense ssRNA viruses in Flaviviridae.

Flavivirus genome — type?

Non-segmented, single polyprotein RNA.

Flavivirus replication — location?

Cytoplasm within ER-derived vesicles.

DENV vectors — primary?

Aedes aegypti and albopictus mosquitoes.

Zika manifestations — congenital?

Microcephaly and congenital Zika syndrome.

Flavivirus entry — mechanism?

Receptor-mediated endocytosis and fusion.

Genome translation — site?

At the ER as a polyprotein.

Viral maturation — process?

prM cleavage in Golgi.

Dengue severity — key factor?

Prior infection and immune enhancement.

Zika — neurological complication?

Guillain-Barré syndrome.

Picornaviruses — classification?

(+): ssRNA, non-enveloped, T=3 capsid.

Poliovirus vaccine — type?

Inactivated (Salk) and live attenuated (Sabin).

Salk vaccine — characteristic?

Inactivated, no reversion risk.

Sabin vaccine — advantage?

Oral, induces intestinal immunity.

Vaccine reversion — risk?

Sabin vaccine can mutate back to neurovirulent form.

cVDPV — meaning?

Vaccine-derived poliovirus from mutated Sabin strains.

ADE — stands for?

Antibody-dependent enhancement.

ADE — occurs when?

At intermediate cross-reactive antibody titers.

Dengue — severe form?

DHF and DSS with vascular leakage.

NS1 — role in pathogenesis?

Induces endothelial dysfunction and leakage.

Zika — transmission?

Mosquito-borne and vertical (mother to fetus).