Folate antagonists — role?
Inhibit DHFR, block DNA synthesis
Cell cycle phases — target of agents?
Mainly S-phase
Topoisomerase II — function?
Relaxes DNA during replication and transcription
Main drug classes — examples?
Antimetabolites, alkylating agents, antibiotics, microtubule inhibitors
P-glycoprotein — mechanism?
Efflux pump reducing intracellular drug concentration
Folate antagonists — function?
Inhibit DHFR, block nucleotide synthesis
Alkylating agents — DNA effect?
Form covalent crosslinks, cause DNA damage
P-glycoprotein — role?
Efflux transporter, causes drug resistance
Microtubule inhibitors — arrest at?
Metaphase during mitosis
Multidrug resistance — mechanism?
P-gp efflux, reduced drug uptake, increased repair
Teste dein Wissen mit 9 Fragen zu Classical Anticancer Agents Overview.
1. Which feature distinguishes taxanes from vinca alkaloids in their mechanism of microtubule inhibition?
2. Which phase of the cell cycle do classical anticancer agents primarily target?
Überprüfe den vollständigen Kurs im Lernzettel zu Classical Anticancer Agents Overview.
Lernzettel ansehen →Importiere deinen Kurs und die KI erstellt in 30 Sekunden Karteikarten.
Karteikarten-Generator