GLUTs — function?
Facilitate glucose transport across membranes.
GLUTs — transport mechanism?
Facilitated diffusion without ATP.
Hexokinase vs Glucokinase — difference?
Hexokinase has low Km, feedback-inhibited; glucokinase has high Km, not inhibited.
GLUT1 — tissue?
High in brain and erythrocytes.
PFK1 — regulation?
Allosterically regulated by ATP, ADP, citrate, and F2,6P.
GLUT2 — role?
Glucose sensor in liver and pancreas.
Insulin-regulated GLUT?
GLUT4 translocates in muscle and adipose.
Km — significance?
Indicates transporter affinity for glucose.
Hexokinase — regulation?
Inhibited by G6P, high affinity for glucose.
Glucokinase — characteristic?
High Km, no feedback inhibition, in liver.
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1. What is the primary role of glucose phosphorylation enzymes in metabolism?
2. Which GLUT isoform acts as a glucose sensor in the liver and pancreas?
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