What is the rank of malignant ovarian tumors among gynecologic malignancies?
They are the second most common gynecologic malignancy after endometrial cancer.
Ovarian tumor risk factors?
BRCA mutations, Lynch syndrome, family history, nulliparity, early menarche, late menopause, endometriosis, obesity, hormone therapy.
What is the lifetime risk of ovarian cancer in women?
About 1 in 70 women develop ovarian cancer in their lifetime.
Most common ovarian tumor type?
Epithelial tumors at 90%.
What are the main WHO 2020 categories of malignant ovarian tumors?
Epithelial tumors, germ-cell tumors, sex-cord stromal tumors, and metastatic tumors.
High-grade serous carcinoma?
Aggressive, TP53 mutation, common subtype.
How do high-grade and low-grade serous carcinomas differ genetically?
High-grade has TP53 mutation; low-grade has KRAS or BRAF mutation.
Tumor marker for ovarian cancer?
CA-125.
Proposed origin of high-grade serous?
Serous tubal intraepithelial carcinoma (STIC).
Germ-cell tumors types?
Dysgerminoma, yolk-sac, immature teratoma, choriocarcinoma.
Protective factors against ovarian cancer?
Oral contraceptives, multiparity, breastfeeding, tubal ligation.
Test your knowledge with 11 questions on Malignant Ovarian Tumors.
1. What is the epidemiologic relationship between malignant ovarian tumors and other gynecologic malignancies?
2. What is the primary origin of approximately 90% of ovarian malignancies?
Review the complete course in the study sheet for Malignant Ovarian Tumors.
See study sheet →Import your course and AI generates flashcards in 30 seconds.
Flashcard generator