GLUTs — function?
Facilitate glucose transport across membranes.
GLUTs — transport mechanism?
Facilitated diffusion without ATP.
Hexokinase vs Glucokinase — difference?
Hexokinase has low Km, feedback-inhibited; glucokinase has high Km, not inhibited.
GLUT1 — tissue?
High in brain and erythrocytes.
PFK1 — regulation?
Allosterically regulated by ATP, ADP, citrate, and F2,6P.
GLUT2 — role?
Glucose sensor in liver and pancreas.
Insulin-regulated GLUT?
GLUT4 translocates in muscle and adipose.
Km — significance?
Indicates transporter affinity for glucose.
Hexokinase — regulation?
Inhibited by G6P, high affinity for glucose.
Glucokinase — characteristic?
High Km, no feedback inhibition, in liver.
Teste seu conhecimento com 10 perguntas sobre Glucose Metabolism Mastery.
1. What is the primary role of glucose phosphorylation enzymes in metabolism?
2. Which GLUT isoform acts as a glucose sensor in the liver and pancreas?
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