What type of condition is asthma?
A chronic inflammatory condition of the respiratory mucosa.
Asthma Type
Chronic inflammatory respiratory condition
What causes breathing attacks in asthma?
Narrowing of the respiratory passageways.
Hygiene hypothesis
Reduced pathogen exposure increases asthma susceptibility
What three conditions make up the atopic triad?
Asthma, atopic dermatitis, and atopic rhinitis.
Samter's triad
Asthma, nasal polyps, ASA sensitivity
What does the hygiene hypothesis propose about asthma susceptibility?
Reduced pathogen exposure increases asthma susceptibility by altering leukocyte maturation.
ASA Sensitivity Pathway
COX inhibition increases leukotrienes, causing bronchospasms
Leukotrienes role
Cause bronchospasms, increase vascular permeability, mucus
Allergen recognition
Dendritic cells present allergen to Th2 cells via MHC-II
IgE activation
Binds to mast cells, causing degranulation and mediator release
Test your knowledge with 10 questions on Asthma Pathophysiology.
1. Which feature most completely defines asthma?
2. What is the definition of asthma?
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