Flashcard: Etiopathogenesis of Craniofacial Anomalies — 14 carte

Etiopathogenesis — definition?

Study of disease causes and mechanisms.

Etiology classification — types?

Primary, secondary, tertiary causes.

Primary causes — examples?

Genetic, congenital, pathological, nutritional.

Genetic causes — key genes?

MSX1, TWIST, FGFR1, IRF6, PAX9.

Congenital causes — teratogens?

Alcohol, drugs, tobacco, radiation, hyperthermia.

Pathological causes — examples?

Endocrine disorders, infections like syphilis.

Nutritional deficiencies — impact?

Impair osteogenesis, odontogenesis, eruption.

Genetic theory — main idea?

Form determines function; deformities cause dysfunctions.

Functional theory — main idea?

Function creates form; disorders lead to anomalies.

Synthetic theory — concept?

Genetic, environmental, epigenetic factors influence growth.

Hereditary causes — evidence?

Family studies, twin observations show inheritance.

Teratogenic impact?

Exposure during embryogenesis causes anomalies.

Endocrine diseases — effect?

Alter craniofacial growth and development.

Nutritional deficits — key nutrients?

Calcium, vitamins A, C, D.