Physiological Changes in Older Adults

From the study guide

Course Outline

  1. Definitions and Types of Aging
  2. Microbiological and Macrobiological Theories
  3. Brain and Nervous System Changes
  4. Neurological Disorders in Older Adults
  5. Sensory System Changes
  6. Circulatory and Respiratory Changes
  7. Chronic Disease and Health Risks

1. Definitions and Types of Aging

Key Concepts & Definitions

  • Biological aging: López-Otín dkk. - López-Otín et al. (2023) define aging as the progressive decline of physiological function at cellular and molecular levels, marked by accumulated genetic damage, loss of protein balance, and mitochondrial dysfunction, which increase vulnerability to disease and death.
  • Global health perspective on aging: The WHO (2021) defines aging as the accumulation over time of molecular and cellular damage that gradually reduces physical and mental capacity, increases disease risk, and ultimately leads to death.
  • Primary aging: The universal change that occurs with increasing age and is not caused by disease or environmental influences.
  • Secondary aging: Change involving the interaction of primary aging processes with environmental influences and disease processes.

Essential Points

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Practice quiz preview

1. How do López-Otín et al. (2023) characterize aging?

2. An older adult experiences age-related changes that are compounded by chronic disease and environmental influences. Which type of aging best describes this interaction?

3. In the microbiological theory of aging, how can the accumulation of molecular connections damage cell function?

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Flashcard preview

Which source and year define biological aging as progressive physiological decline?

López-Otín dkk., 2023.

How can aging-cell molecules disrupt cell function in the microbiological theory?

They connect, adhere, and accumulate, potentially stopping vital biochemical cycles and causing further damage.

How does aging affect the immune system’s ability to fight infection?

Its ability to recognize and fight bacteria and viruses diminishes, increasing susceptibility to infection.

When does aging begin?

In early adulthood.

What happens to neuron numbers in older adults?

They lose some neurons.

Which brain regions shrink especially with age?

The prefrontal cortex and hippocampus.

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The practice quiz has 11 multiple-choice questions, each with an explanation. Use it to check what you know and find your gaps.

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