Fundamental Organic Reactions and Syntheses

Revision sheet excerpt

Course Outline

  1. Acetylation Name Reactions
  2. Wurtz Fittig Reaction
  3. Wurtz Reaction
  4. Wolff-Kishner Reduction
  5. Williamson's Reaction
  6. Stephen Reaction
  7. Schotten Baumann Reaction
  8. Sandmeyer’s Reaction
  9. Rosenmund Reaction
  10. Reimer-Tiemann Reaction
  11. Perkin Reaction
  12. Liebermann’s Nitroso Reaction

1. Acetylation Name Reactions

Key Concepts & Definitions

  • Acetylation: A chemical reaction where an acetyl group (CH₃CO−) is introduced into an organic molecule, often to modify reactivity or protect functional groups.
  • Acetyl Group (CH₃CO−): A functional group derived from acetic acid, commonly used in acetylation reactions.
  • Acetyl Chloride (CH₃COCl): A reactive acetylating agent used to introduce acetyl groups into compounds.
  • Acetic Anhydride ((CH₃CO)₂O): Another common acetylating agent, more reactive than acetic acid.
  • Acetylation of Aromatic Compounds: Typically involves electrophilic substitution where the acetyl group attaches to aromatic rings, often facilitated by catalysts like Lewis acids.
  • Protection Strategy: Acetylation is used to temporarily protect hydroxyl or amino groups during multi-step syntheses.

Essential Points

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Quiz preview

1. What is an acetylation name reaction?

2. Who were the chemists responsible for developing the Wurtz Fittig Reaction, and in which years did they publish their key findings?

3. Which of the following reagents and conditions are used in the Wurtz Fittig Reaction to couple aryl halides with alkyl halides?

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Flashcards preview

Acetylation — purpose?

Modifies, protects, or activates functional groups.

Wurtz Fittig Reaction — purpose?

Couples aryl halides to form biaryl compounds.

Wurtz Fittig Reaction — main use?

Couples aryl halides to form biaryl compounds.

Wurtz Reaction — reactants?

Alkyl halides with sodium metal.

Wurtz Reaction — primary product?

Coupled alkane from alkyl halides.

Wurtz Reaction — product?

Alkane or coupled product from halides.

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