CO — binding to hemoglobin?
Reversibly binds, displacing oxygen
CO poisoning — primary cause?
Inhalation of incomplete combustion gases.
CO toxicity — mechanism?
HbCO formation causes hypoxia and mitochondrial inhibition
HbCO levels indicating intoxication?
Above 15%; >50% often fatal.
Organophosphates — action?
Inhibit cholinesterases, causing cholinergic crisis
Organophosphates — mechanism?
Irreversibly inhibit acetylcholinesterase.
Cholinesterase activity — significance?
Confirms organophosphate poisoning.
Psychotropic overdose — systems affected?
CNS, cardiovascular, respiratory.
CO affinity for hemoglobin?
200-250 times that of O2.
Antidotes for organophosphates?
Atropine + pralidoxime.
Pon a prueba tus conocimientos con 9 preguntas sobre Toxicology of Carbon Monoxide, Organophosphates, and Psychotropes.
1. What is the primary mechanism by which carbon monoxide (CO) causes toxicity in the human body?
2. What level of carboxyhemoglobin (%HbCO) typically indicates poisoning, and what level is often fatal according to the revision sheet?
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