Flashcard: Asthma Pathophysiology — 11 carte

What type of condition is asthma?

A chronic inflammatory condition of the respiratory mucosa.

Asthma Type

Chronic inflammatory respiratory condition

What causes breathing attacks in asthma?

Narrowing of the respiratory passageways.

Hygiene hypothesis

Reduced pathogen exposure increases asthma susceptibility

What three conditions make up the atopic triad?

Asthma, atopic dermatitis, and atopic rhinitis.

Samter's triad

Asthma, nasal polyps, ASA sensitivity

What does the hygiene hypothesis propose about asthma susceptibility?

Reduced pathogen exposure increases asthma susceptibility by altering leukocyte maturation.

ASA Sensitivity Pathway

COX inhibition increases leukotrienes, causing bronchospasms

Leukotrienes role

Cause bronchospasms, increase vascular permeability, mucus

Allergen recognition

Dendritic cells present allergen to Th2 cells via MHC-II

IgE activation

Binds to mast cells, causing degranulation and mediator release