Flashcards: Cancer Biology Essentials — 10 cartões

Cancer hallmarks — definition?

Biological traits enabling tumor growth and spread.

Cancer hallmarks — definition?

Biological capabilities enabling tumor growth and spread.

Cell cycle dysregulation — mechanism?

Mutations in genes controlling cell division lead to uncontrolled proliferation.

Sustaining proliferative signaling — role?

Allows continuous growth stimulation in cancer cells.

Tumor microenvironment — components?

Includes stromal cells, immune cells, ECM, and signaling molecules.

Evading growth suppressors — example?

Inactivation of p53 or RB.

Resisting cell death — mechanism?

Avoiding apoptosis through pathway mutations.

Enabling replicative immortality — factor?

Telomerase activation maintains telomeres.

Angiogenesis — process?

Tumors stimulate new blood vessel formation.

Invasion and metastasis — ability?

Cancer spreads to distant sites.