CO — binding to hemoglobin?
Reversibly binds, displacing oxygen
CO poisoning — primary cause?
Inhalation of incomplete combustion gases.
CO toxicity — mechanism?
HbCO formation causes hypoxia and mitochondrial inhibition
HbCO levels indicating intoxication?
Above 15%; >50% often fatal.
Organophosphates — action?
Inhibit cholinesterases, causing cholinergic crisis
Organophosphates — mechanism?
Irreversibly inhibit acetylcholinesterase.
Cholinesterase activity — significance?
Confirms organophosphate poisoning.
Psychotropic overdose — systems affected?
CNS, cardiovascular, respiratory.
CO affinity for hemoglobin?
200-250 times that of O2.
Antidotes for organophosphates?
Atropine + pralidoxime.
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1. What is the primary mechanism by which carbon monoxide (CO) causes toxicity in the human body?
2. What level of carboxyhemoglobin (%HbCO) typically indicates poisoning, and what level is often fatal according to the revision sheet?
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