★ Must-know
📌 Primary hypothyroidism originates in the thyroid and is associated with elevated TSH, central hypothyroidism originates in the pituitary or hypothalamus and is associated with normal or decreased TSH, and peripheral hypothyroidism is extra-thyroidal and is associated with elevated TSH.
Further detail
1. What best defines hypothyroidism?
2. Which laboratory pattern most strongly suggests central hypothyroidism?
3. Which complication can result from untreated hypothyroidism?
What is hypothyroidism?
Reduced thyroid function causing slowed cellular activities due to decreased thyroid hormone.
Where does primary hypothyroidism originate and what is TSH level?
In the thyroid with elevated TSH.
Where does central hypothyroidism originate and what is TSH level?
In the pituitary or hypothalamus with normal or decreased TSH.
Where does peripheral hypothyroidism originate and what is TSH level?
Extra-thyroidal with elevated TSH.
What complications can untreated hypothyroidism cause?
Cardiovascular, hematopoietic, metabolic, obstetric, fetal, neonatal, childhood complications, and myxedematous coma.
How does hypothyroidism prevalence change with age in adults?
It increases with age.
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